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James Murdoch scaled the rungs of the global media empire that his father built. Now scandal taints the heir apparent, threatening to derail the expected succession and shaking the assumption that the Murdoch dynasty would preserve its tight grip over the multibillion-dollar business. HT Image Founder Rupert Murdoch, 80, has long expressed a wis <a href=https://www.stanley-germany.de>stanley cup</a> h to hand his publicly traded News Corp. to his offspring, and he retains the voting power to make key decisions. But shareholders and board members are said to be troubled by revelations of wrongdoing on Murdoch s watch, and feel the US-based company needs fresh leadership. A pivotal moment for the family comes on Tuesday when the media mogul and his son testify before British lawmakers investigating the hacking and alleged police bribery at a now-shuttered tabloid, News of the World. The future is looking increasingly gray for James Murdoch, said Ivor Gaber, professor of political journalism at City University London. There are now investors, particularly in the United States, who are suggesting that the time has come to end the Murdochs dynastic hold on News C <a href=https://www.cup-stanley-cup.co.uk>stanley cup</a> orp. Some analysts believe Murdoch is positioning 42-year-old daughter Elisabeth as a successor in the event that 38-year-old James, chief executive of his father s European and Asian operations, is forced to step aside or faces arrest. Ric <a href=https://www.cup-stanley.ca>stanley cup</a> hard Hillgrove, a London-based public relations consultant and former commentator for Murdoch-owned newspapers in New Zeala Zusb Sharia laws formally imposed in Swat
Scientists have discovered a novel way to block pain at its source. HT Image A research team at The University of <a href=https://www.nikeairforce.es>af1</a> Texas Health Science Center at San Antonio says that a substance similar to capsaicin, which gives chili peppers th <a href=https://www.nikedunk.us>nike dunk</a> eir heat, is generated at the site <a href=https://www.nike-dunks.de>nike dunk</a> of pain in the human body. And blocking the production of this substance can stop chronic pain, the team found. Capsaicin is the primary ingredient in hot chilli peppers, which causes a burning sensation. It does this by binding to receptors present on the cells inside the body. Similarly, when the body is injured, it releases capsaicin-like substances - fatty acids called oxidized linoleic acid metabolites or OLAMs - and these, via receptors, cause pain, the researchers have found. Dr Kenneth Hargreaves, senior researcher at the Dental School at the University of Texas, and his team next set out to see if they could block these newly discovered pain pathways. Lab work on mice showed that by knocking out a gene for the receptors, there was no sensitivity to capsaicin. Armed with this knowledge they set about making drugs to do the same. This is a major breakthrough in understanding the mechanisms of pain and how to more effectively treat it. We have discovered a family of endogenous capsaicin-like molecules that are naturally released during injury, and now we understand how to block these mechanisms with a new class of non-addictive therapies, Dr Hargreaves said. Ultimately, he hopes the drugs w
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